Abstract:
Since the presence of metabolic diseases such as type two diabetes mellius, obesity and insulin resistance syndrome are increasing rapidly and relentlessly, it becomes necessary to define the genetic and molecular basics of insulin resistance. The focus of this research will be to identify and characterize these diseases using in vivo methods such as exercise training, muscle biopsies and euglycemic hyperinsulinemic clamps. Exercise training consists of aerobic exercises and strength training through which an individual’s ability to cooperate with insulin increases, strengthening the heart and bones, improving blood circulation and eventually contributing to lower blood glucose and pressure levels. Muscle biopsy is a procedure that uses a piece of an individual’s muscle tissue for further research and examinations. Euglycemic Hyperinsulinemic clamps test an individual’s reactions towards insulin and their ability to metabolize glucose. Genes that are identified from these analyses are narrowed even further using assays in order to closely study the functions of each of the eligible genes. The identification of the genes that contribute to insulin resistance is the most crucial part of this study. This is mainly because that gene later becomes the objective of therapeutic inventions which assists in either improving the decreasing process of insulin resistance or completely reversing it, and the results of this procedure leads to the improvement of many of these common metabolic diseases.
Since the presence of metabolic diseases such as type two diabetes mellius, obesity and insulin resistance syndrome are increasing rapidly and relentlessly, it becomes necessary to define the genetic and molecular basics of insulin resistance. The focus of this research will be to identify and characterize these diseases using in vivo methods such as exercise training, muscle biopsies and euglycemic hyperinsulinemic clamps. Exercise training consists of aerobic exercises and strength training through which an individual’s ability to cooperate with insulin increases, strengthening the heart and bones, improving blood circulation and eventually contributing to lower blood glucose and pressure levels. Muscle biopsy is a procedure that uses a piece of an individual’s muscle tissue for further research and examinations. Euglycemic Hyperinsulinemic clamps test an individual’s reactions towards insulin and their ability to metabolize glucose. Genes that are identified from these analyses are narrowed even further using assays in order to closely study the functions of each of the eligible genes. The identification of the genes that contribute to insulin resistance is the most crucial part of this study. This is mainly because that gene later becomes the objective of therapeutic inventions which assists in either improving the decreasing process of insulin resistance or completely reversing it, and the results of this procedure leads to the improvement of many of these common metabolic diseases.
For the in vivo methods, have you narrowed your focus to only diabetes and insulin resistant syndromes? Do you think you will be able to characterize and come across other related diseases/conditions during your experimentation and research?
ReplyDeleteI will probably come across other related diseases but I'll be focusing on diabetes, insulin resistance, and obesity for this research especially for the results I will get from Euglycemic Hyperinsulinemic clamps because the purpose of those is to test reactions towards insulin and the ability of metabolizing glucose.
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